Genetically Polymerized is a text-based game that follows a private investigator by the name of Jesse as he boards a transport pod with his partner Katherine to take a vacation on another planet. As part of his payment for his last job, he is provided this vacation and a treatment, known as “the procedure,” to bind animal DNA to his own, giving him numerous minor traits. To travel to his resort destination, he has to travel on a preperatory pod with several other vacationers who have also had “the procedure.” He forms bonds with them as they travel through space, eventually forming an intimate relationship with them all.